Radioisotopes Manufacturing Program Manager
About this role
Lead all aspects of actinium-225 manufacturing operations for TerraPower Isotopes, managing day-to-day production in GMP-aligned hot cell and glovebox environments. This role requires strong technical expertise and proven leadership in regulated nuclear or radiopharmaceutical manufacturing to ensure safe, compliant, and efficient production of radioisotopes for advanced cancer therapies.
Responsibilities
- —Own end-to-end manufacturing performance including production planning, throughput, yield, and resource allocation
- —Lead day-to-day operations within hot cell and glovebox environments while ensuring compliance with GMP, radiological, and safety requirements
- —Oversee execution, review, and continuous improvement of production processes, batch documentation, and data integrity practices
- —Drive troubleshooting and technical issue resolution in coordination with radiochemists, engineers, radiation safety, quality, and industrial safety teams
- —Ensure operations comply with FDA expectations for API starting material production, NRC and DOT radioactive material requirements, and applicable state and OSHA regulations
- —Partner with Quality on deviations, CAPAs, nonconformances, change controls, and internal/external audits
- —Maintain validated processes and equipment, ensuring changes follow approved validation and change control pathways
- —Coordinate with Everett Laboratory Manager to align manufacturing needs with facility activities
- —Work with Maintenance Engineering and Facility Maintenance to plan outages and maintain equipment readiness
- —Collaborate with Logistics to maintain adequate inventories of consumables and production-support materials
- —Partner with Radiation Safety and Health Physics on radiological work planning, radioactive materials inventory, contamination control, and waste handling
Qualifications
- —Bachelor's degree in chemical engineering, radiochemistry, pharmaceutical sciences, or related laboratory or engineering discipline
- —Minimum 8 years of experience working with radioactive materials under an established radiation protection program
- —Strong working knowledge of FDA regulations for pharmaceutical/API starting materials, NRC and DOT regulations for radioactive materials, and applicable state health and OSHA requirements
- —Demonstrated ability to lead technical teams, manage priorities, and coordinate cross-functional work in a high-hazard environment
- —Effective written and verbal communication skills in English
Desired
- —Alpha-emitter experience
- —Leadership or supervisory experience in a regulated manufacturing environment (radiopharmaceutical, nuclear pharmacy, GMP chemical manufacturing, or comparable field)
- —Military experience
Location
Washington State-based; 0-10% travel required; extended periods sitting, visual and audio focused work in standard office and hot cell/glovebox environments; ability to safely lift up to 25 pounds
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Job details
About the company
TerraPower →A nuclear innovation company founded by Bill Gates, building the Natrium sodium-cooled fast reactor and advancing medical isotope production.
Careers page ↗Radioisotopes Manufacturing Program Manager
TerraPower